Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation

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Researchers showed that airway basal stem cells (BSCs) derived from tracheal aspirates (TA) of control patients are bona fide bronchial BSCs. TA BSCs from CoV19 patients tested negative for SARS-CoV-2 RNA; however, these so-termed CoV19-exposed BSCs in vitro resembled a predominant BSC subpopulation uniquely present in CoV19 patients.
[American Journal Of Respiratory Cell And Molecular Biology]
Abstract