DUX4 Expression in Cancer Induces a Metastable Early Embryonic Totipotent Program

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Researchers identified cancer cell lines that express DUX4 and showed that DUX4 is transiently expressed in a small subset of the cells. DUX4 expression activates the DUX4-regulated ZGA transcriptional program, the subsequent 8C-like program, and markers of early embryonic lineages, while suppressing steady-state and interferon-induced MHC class I expression.
[Cell Reports]
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