The Guanine Nucleotide Exchange Factor Rin-Like Controls Tfh Cell Differentiation via CD28 Signaling

Loss of the guanine nucleotide exchange factor Rin-like led to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures.
[Journal Of Experimental Medicine]

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