The SGLT2 Inhibitor Canagliflozin Suppresses Growth and Enhances Prostate Cancer Response to Radiotherapy
Scientists showed that well-tolerated doses of canagliflozin suppressed proliferation and survival of androgen-sensitive and insensitive human prostate cancer cells and tumors and sensitize them to radiotherapy.
[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.
[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.
[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.