Activation of the Transcription Factor NFAT5 in the Tumor Microenvironment Enforces CD8+ T Cell Exhaustion

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Researchers found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8+ T cells in the context of chronic infections and tumors but was selectively required in tumor-induced CD8M+ T cell exhaustion.
[Nature Immunology]
Abstract