Activation of Melanocortin-1 Receptor Signaling in Melanoma Cells Impairs T Cell Infiltration to Dampen Antitumor Immunity
Scientists reported that loss of melanocortin-1 receptor in melanoma cells activates antitumor T cell response and overcomes resistance to immune checkpoint blockade.
[Cell & Bioscience] Scientists demonstrated that CDK1 was correlated with prognosis and was highly expressed in pancreatic cancer tissue and gemcitabine-resistant cells
[Acta Biomaterialia] Researchers demonstrated that incorporating human pancreatic decellularized extracellular matrix within alginate microcapsules resulted in a significant increase in Glucose Stimulation Index and total insulin secreted by encapsulated human islets, compared to free islets and islets encapsulated in only alginate.
[Cancer Letters] In vivo and in vitro experiments revealed that FABP4 induced macrophage-related inflammation to promote pancreatic cancer cell migration, invasion, and metastasis under obese condition.