Deletion of Endothelial TRPV4 Protects Heart from Pressure Overload–Induced Hypertrophy

The authors measured microvascular density and underlying TRPV4 mechanotransduction mechanisms using human microvascular endothelial cells, extracellular matrix gels of varying stiffness, unbiased RNA sequencing, siRNA, Western blot, qPCR, and confocal immunofluorescence techniques.

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