Pd-1 Instructs a Tumor-Suppressive Metabolic Program That Restricts Glycolysis and Restrains Ap-1 Activity in T Cell Lymphoma

Using tractable mouse models for T cell non-Hodgkin lymphomas and primary patient samples, investigators demonstrated that PD-1 signaling suppressed T cell malignancy by restricting glycolytic energy and acetyl coenzyme A production.
[Nature Cancer]
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