Aberrant Gene Activation in Synovial Sarcoma Relies on SSX Specificity and Increased PRC1.1 Stability

Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.
[Nature Structural & Molecular Biology]
Full Article