UGDH Promotes Tumor-Initiating Cells and a Fibroinflammatory Tumor Microenvironment in Ovarian Cancer

To target tumor-initiating cells (TICs) to prevent recurrence, researchers identified genes critical for TIC viability from a whole genome siRNA screen. A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH).