Netrin-1 Feedforward Mechanism Promotes Pancreatic Cancer Liver Metastasis via Hepatic Stellate Cell Activation, Retinoid, and ELF3 Signaling

Investigators detected an upregulation of the neuronal axon guidance molecule Netrin-1 in PDAC liver metastases that signals through its dependence receptor, uncoordinated-5b, to facilitate metastasis in vitro and in vivo.