HNF1α Maintains Pancreatic α and β Cell Functions in Primary Human Islets

Investigators combined conditional genetic targeting in human islet cells, RNA sequencing, chromatin mapping with Cleavage Under Targets & Release Using Nuclease, and transplantation-based assays to determine HNF1α-regulated mechanisms in adult human pancreatic α and β cells.
[JCI Insight]
AbstractGraphical Abstract
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