FOXO Inhibition Rescues α-Defensin Expression in Human Intestinal Organoids

Investigators reported that the expression profile of antimicrobials produced by Paneth cells was dramatically askew in human small intestinal organoids as compared to that in paired tissue from which they were derived, with a reduction of α-defensins to nearly undetectable levels.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
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