Epidermal Growth Factor Receptor Activation Is Essential for Kidney Fibrosis Development

In vivo and in vitro studies and single-nucleus RNA sequencing analysis demonstrated that EGFR activation did not induce myofibroblast transformation but was necessary for the initial pericyte/fibroblast migration and proliferation prior to subsequent myofibroblast transformation by TGF-ß or other profibrotic factors.
[Nature Communications]
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