Identification of a Small-Molecule Tim-3 Inhibitor to Potentiate T Cell–Mediated Antitumor Immunotherapy in Preclinical Mouse Models

Using a strategy combining virtual and functional screening, researchers identified a compound named ML-T7 that targeted the FG-CC′ cleft of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3).
[Science Translational Medicine]

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