Invasion-Block and S-MARVEL: A High-Content Screening and Image Analysis Platform Identifies ATM Kinase as a Modulator of Melanoma Invasion and Metastasis

Abrogation of Ataxia-telangiectasia mutated (ATM) kinase inhibitors expression in melanoma cells via CRISPR-mediated gene knockout reduced 3D invasion in vitro as well as spontaneous lymph node metastasis in vivo.