Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T Cell Function

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Researchers showed that the genetic disruption of SUV39H1, which encodes a histone-3, lysine-9 methyl-transferase, enhanced the early expansion, long-term persistence, and overall anti-tumor efficacy of human CAR T cells in leukemia and prostate cancer models.
[Cancer Discovery]
Abstract