Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy

The authors reported that the activity of cyclin-dependent kinase 5 (Cdk5) and the conversion of its activating subunit p35 to the more potent activator p25 were significantly up-regulated in mouse models and human induced pluripotent stem cell models of spinal muscular atrophy.