Ceftriaxone Exerts Antitumor Effects in MYCN-Driven Retinoblastoma and Neuroblastoma by Targeting DDX3X for Translation Repression
Using patient-derived tumor organoids and tumor cell lines, investigators demonstrated that ceftriaxone was a potent and selective growth inhibitor targeting MYCN-driven retinoblastoma and neuroblastoma cells.
[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.
[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.
[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.