LAIR-1 Agonism as a Therapy for Acute Myeloid Leukemia

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The authors developed a therapeutic LAIR-1 agonist antibody, NC525, that induced cell death of leukemic stem cells (LSCs), but not healthy hematopoietic stem cells in vitro, and killed LSCs and AML blasts in both cell- and patient-derived xenograft models.
[Journal Of Clinical Investigation]
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