CerS6-Dependent Ceramide Synthesis in Hypothalamic Neurons Promotes ER/Mitochondrial Stress and Impairs Glucose Homeostasis in Obese Mice

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Scientists found increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.
[Nature Communications]
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