Myeloid OTULIN Deficiency Couples RIPK3-Dependent Cell Death to Nlrp3 Inflammasome Activation and IL-1β Secretion

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Scientists identified OTULIN deficiency as a cellular condition that licenses RIPK3-mediated cell death in murine macrophages, leading to Nlrp3 inflammasome activation and subsequent IL-1β secretion.
[Science Immunology]
Abstract