GPIbα CAAR-T Cells Function Like a Trojan Horse to Eliminate Autoreactive B Cells to Treat Immune Thrombocytopenia

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The authors engineered human T cells to express a chimeric autoantibody receptor (CAAR) with GPIbα constructed into the ligand-binding domain fused to the CD8 transmembrane domain and CD3ζ-4-1BB signaling domains.
[Haematologica]
Abstract