Inhibition of CD38 Enzymatic Activity Enhances CAR-T Cell Immune-Therapeutic Efficacy by Repressing Glycolytic Metabolism

By performing single-cell multi-omics data analysis on patient-derived CAR-T cells, scientists identified CD38 as a potential hallmark of exhausted CAR-T cells, which was positively correlated with exhaustion-related transcription factors and further confirmed with in vitro exhaustion models.