TwinF Interface Inhibitor FP802 Stops Loss of Motor Neurons and Mitigates Disease Progression in a Mouse Model of ALS

The authors took advantage of TwinF interface inhibition that, contrary to classical NMDAR pharmacology, allowed selective elimination of extrasynaptic NMDA receptor-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex while sparing the vital physiological functions of synaptic NMDARs.
[Cell Reports Medicine]
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