Ultrahigh Frequencies of Peripherally Matured LGI1- and CASPR2-Reactive B Cells Characterize the Cerebrospinal Fluid in Autoimmune Encephalitis

Scientists everaged two common forms of autoimmune encephalitis, mediated by leucine-rich glioma inactivated-1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies, as human models to comprehensively reconstruct and profile cerebrospinal fluid B cell receptor characteristics.