IL-8 Activates Fibroblasts to Promote the Invasion of HNSCC Cells via STAT3-MMP1

Researchers demonstrated a part of crosstalk between fibroblasts and cancer cells that enhanced the invasiveness of cancer cells, IL8-induced activation of STAT3 signaling pathway as a key promoter to elevated matrix metalloproteinase-1 (MMP1) level in fibroblasts that supports the migration and invasion of head and neck squamous cell carcinoma (HNSCC) cells by extracellular matrix degradation.