The LRRK2 Kinase Substrates RAB8a and RAB10 Contribute Complementary but Distinct Disease-Relevant Phenotypes in Human Neurons

Researchers used CRISPR-Cas9 genome editing to generate a novel series of isogenic iPSC lines deficient in the two most well-validated LRRK2 substrates, RAB8a and RAB10, from deeply phenotyped healthy control lines.
[Stem Cell Reports]
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