PRAMEL7 and CUL2 Decrease NuRD Stability to Establish Ground-State Pluripotency

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Investigators RAMEL7 recruited CUL2 to chromatin and targeted regulators of repressive chromatin, including the NuRD complex, for proteasomal degradation. PRAMEL7 antagonized NuRD-mediated repression of genes implicated in pluripotency by decreasing NuRD stability and promoter association in a CUL2-dependent manner.
[EMBO Reports]
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