Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation

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Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion.
[JCI Insight]
Abstract