Development of Certain Benzylidene Coumarin Derivatives as Anti-Prostate Cancer Agents Targeting EGFR and PI3Kβ Kinases

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Novel coumarin derivatives were synthesised and tested for their cytotoxicity against human cancer cells. Compounds 5, 4b, and 4a possessed potent cytotoxic activity against PC-3 cells with IC50 3.56, 8.99, and 10.22 µM, respectively.
[Journal Of Enzyme Inhibition And Medicinal Chemistry]
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