Identification of Critical Process Parameters for Expansion of Clinical Grade Human Wharton’s Jelly-Derived Mesenchymal Stromal Cells in Stirred-Tank Bioreactors

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The feasibility of transitioning was evaluated from an established Wharton’s jelly MSCs 2D production strategy to a new one with stirred-tank bioreactors. Experimental conditions included four GMP-compliant xeno- and serum-free media screened in 2D conditions and two GMP-grade microcarriers assessed in 0.25 L-STRs using serum-containing media.
[Biotechnology Journal]
Abstract