Select EZH2 Inhibitors Enhance Viral Mimicry Effects of DNMT Inhibition through a Mechanism Involving NFAT:AP-1 Signaling

Researchers reported that colorectal cancer cells that are insensitive to single-agent enhancer of zeste homolog 2 (EZH2) inhibition become sensitive as compensatory lysine-27 trimethylation on histone H3 mediated silencing emerges upon DNA methyltransferase inhibitor (DNMTi) treatment.