Methyl-CpG Binding Domain Protein 2 (Mbd2) Drives Breast Cancer Progression through the Modulation of Epithelial-to-Mesenchymal Transition

To test whether Mbd2 plays a causal role in mammary tumor growth and metastasis, the authors performed genetic knockout (KO) of Mbd2 in transgenic mice and compared mammary tumor progression kinetics between the wild-type and KO groups.