Regulatory T Cells Expressing CD19-Targeted Chimeric Antigen Receptor Restore Homeostasis in Systemic Lupus Erythematosus

In an humanized mouse model of Systemic Lupus Erythematosus, a single infusion of Fox19CAR-Tregs restricts autoantibody generation, delayed lymphopenia and restored the human immune system composition in lymphoid organs, without detectable toxicity.
[Nature Communications]
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