Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

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Using comprehensive genomic profiling among >600,000 patients, scientists identified activating MET tyrosine kinase domain point mutations as putative oncogenic driver across diverse cancers, with a frequency of ~0.5%.
[Cancer Discovery]
Abstract