Targeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity Syndrome

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Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.
[Nature Cancer]
Abstract