NewslettersCell Therapy NewsTargeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity SyndromeBy Jamie Kang - May 13, 2024076Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.[Nature Cancer]Abstract