Stealth Transgenes Enable CAR-T Cells to Evade Host Immune Responses

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Scientists implemented a one-shot approach to prevent rejection of engineered T cells by simultaneously reducing antigen presentation and the surface expression of both Classes of the major histocompatibility complex (MHC) via expression of the viral inhibitors of transporter associated with antigen processing in combination with a transgene coding for shRNA targeting class II MHC transactivator.
[Journal For Immunotherapy Of Cancer]
Abstract