Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury

Scientists studied the function of homeobox-containing 1 (Hmbox1) in exercise-induced physiological cardiac growth in mice after four weeks of swimming exercise. Hmbox1 expression was then evaluated in human heart samples from deceased patients with myocardial infarction and in the animal cardiac ischemia/reperfusion injury model.