A JAGN1-Associated Severe Congenital Neutropenia Zebrafish Model Revealed an Altered G-CSFR Signaling and UPR Activation

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There is a limited availability of primary HSCs from JAGN1-congenital neutropenia (CN) patients and the absence of animal models to study the mechanism by which autosomal recessive mutations in the JAGN1 gene cause severe CN. Scientists addressed these limitations by establishing a zebrafish model of JAGN1-CN.
[Blood Advances]
Abstract