CD271 mRNA/hnRNPA2B1 Complex Promotes Proliferation and Stemness in Oral and Head and Neck Squamous Cell Carcinoma

The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.