A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease

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Researchers utilized single-cell RNA-seq and single-cell multiomics approaches in primary human monocyte–derived macrophages to explore the transcriptional regulatory network involved in a critical pathogenic event of coronary atherosclerosis—the formation of lipid-laden foam cells.
[Circulation Research]
AbstractGraphical Abstract