The Mechanosensory Channel PIEZO1 Functions Upstream of Angiopoietin/TIE/FOXO1 Signaling in Lymphatic Development

Investigators identified crosstalk between piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells caused rapid exocytosis of the TIE ligand ANGPT2 and more.