A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat Following BRAF and MEK Inhibitors in BRAFV600 mutated Melanoma

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Scientists assessed the anti-tumor activity of sequential treatment with vorinostat following BRAF and MEK inhibitors (BRAFi/MEKi) in patients with BRAFV600 melanoma who progressed after initial response to BRAFi/MEKi.
[Clinical Cancer Research]
Abstract