Oncostatin M Induces a Pro-Inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts

The mRNA and protein expression of oncostatin-M and its receptors, gp130, and several fibrotic and chemotactic factors were studied in mucosal biopsies and isolated human intestinal subepithelial myofibroblasts of patients with inflammatory bowel disease and healthy controls and in a model of human intestinal organoids.