Modeling Blood-Brain Barrier Formation and Cerebral Cavernous Malformations in Human PSC-Derived Organoids

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Researchers constructed human blood-brain barrier (hBBB) assembloids from brain and blood vessel organoids derived from human pluripotent stem cells. They validated the acquisition of BBB-specific molecular, cellular, transcriptomic, and functional characteristics and uncovered extensive neuro-vascular crosstalk with a spatial pattern within hBBB assembloids.
[Cell Stem Cell]
AbstractGraphical Abstract