SDHAF1 Confers Metabolic Resilience to Aging Hematopoietic Stem Cells by Promoting Mitochondrial ATP Production

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Researchers reported that HSCs acquired metabolic resilience that promoted cell survival. High-resolution real-time ATP analysis with glucose tracing and metabolic flux analysis revealed that old HSCs reprogrammed their metabolism to activate the pentose phosphate pathway.
[Cell Stem Cell]
AbstractGraphical Abstract