EHMT2-Mediated Transcriptional Reprogramming Drives Neuroendocrine Transformation in Non–Small Cell Lung Cancer

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Researchers developed preclinical neuroendocrine (NE) transformation models. Next, they identified a transcriptional reprogramming mechanism that drove resistance to erlotinib in NE transformation cell lines and cell-derived xenograft mice.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract