Obesity-Driven Mitochondrial Dysfunction in Human Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Involves Epigenetic Changes

MSCs were harvested from abdominal subcutaneous fat of obese and age/sex-matched non-obese subjects. The 5hmC profile and expression of nuclear-encoded mitochondrial genes were examined by hydroxymethylated DNA immunoprecipitation sequencing and mRNA-seq, respectively.