IL-6 Inhibition Prevents Costimulation Blockade-Resistant Allograft Rejection in T Cell-Depleted Recipients by Promoting Intragraft Immune Regulation in Mice

Scientists investigated why anti-thymocyte globulin (ATG) failed to prevent costimulation blockade-resistant rejection and how this barrier could be overcome. While ATG improved the balance between regulatory T cells and effector T cells in the spleen, it had no such effect within cardiac allografts.